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     Beta-Amyloid 1-40, HFIP
     3XFlag peptide
     MOG 35-55
     Beta-Amyloid 1-42, HFIP
     Beta-Amyloid 1-42, TFA
     Beta-Amyloid 1-40, TFA

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    上海捷妮泰生物科技有限公司
    GenicBio
    Beta-Amyloid 1-42 | Aβ1–42, Human

    Beta-Amyloid 1-42 | Aβ1–42, Human


     
        货号 数量 价格(元) 货期
        A-42-T-1 1 mg ¥800.00 1~2天
        A-42-T-5 5 mg 询价 1~2天
        A-42-T-10 10 mg 询价 1~2天

      英文别名: Aβ42 | Aβ1-42 | Abeta42 | Abeta 1-42 | Amyloid-β42 | β-Amyloid 1-42
      中文名: β-淀粉样多肽 1-42 | Beta-淀粉样多肽 1-42 | Beta-淀粉样多肽 -42 | Β-淀粉样多肽(1-42) | Beta-Amyloid多肽(1-42)
      纯度: >95% by HPLC
      序列(单字母): DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
      (三字母序列): Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile- Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala
      CAS No.: 107761-42-2
      分子式: C203H311N55O60S
      分子量: 4514.14
      外观: 白色粉末
      等电点: 5.2
      净电荷(PH=7): -2.7
      平均亲水性: -0.1
      亲水残基比例: 31%
      盐: TFA
      来源: 化学合成
      储存条件(冻干粉): -20°C(1年) 或 -80°C(1-2年)
      溶解条件: Acetic acid/water (3:2) or DMSO
      运输条件: 常温(加冰袋)
      描述: Alzheimer's disease is a common neurodegenerative, progressive, and fatal disorder. Generation and deposition of amyloid beta (Aβ) peptides associate with its pathogenesis and small soluble Aβ oligomers show the most pronounced neurotoxic effects and correlate with disease initiation and progression.
    Beta amyloid 1-42 is a 42-amino acid peptide which plays a key role in the pathogenesis of Alzheimer, even slightly increased amounts of this Aβ(1–42) might be sufficient to cause Alzheimer's disease (AD).
     
     
       Product Citations Einfluss der sauren Sphingomyelinase auf die Makrophagenaktivierung durch Alzheimer Amyloid Protein (2012)
    Product Name: Beta-amyloid 1-42(GenicBio)
    Author List: Herrn Prof. Dr. Fa?bender, Herrn Dr. Liu und Herrn Dipl.-Biol. Xie danke ich vielmals
    Journal: der Medizinischen Fakult?t der UNIVERSIT?T DES SAARLANDES
     


    Transgenic Overexpression of the Disordered Prion Protein N1 Fragment in Mice Does Not Protect Against Neurodegenerative Diseases Due to Impaired ER Translocation (2020)
    Product Name: Beta-amyloid 1-42(GenicBio)
    Author List: Behnam Mohammadi, Luise Linsenmeier,Mohsin Shafiq, etc.
    Journal: Journal of Molecular Neurobiology
    Doi: https://doi.org/10.1007/s12035-020-01917-2
         
        An analog derived from phenylpropanoids ameliorates Alzheimer's disease–like pathology and protects mitochondrial function (2019)
    Product Name: Beta-amyloid 1-42(GenicBio)
    Author List: Shichao Huang,Xin Caob, Yue Zhou, Fuchun Shi, Gang Pei, etc.
    Journal: Neurobiology of Aging
    Doi: https://doi.org/10.1016/j.neurobiolaging.2019.05.002
         
        Modulation of OSCP mitigates mitochondrial and synaptic deficits in a mouse model of Alzheimer’s pathology(2019)
    Product Name: Beta-amyloid 1-42(GenicBio)
    Author List: Esha Gauba, Shaomei Sui, Jing Tian, Christopher Driskill, etc.
         
        The Neuroprotective Action of Amidated-Kyotorphin on Amyloid β Peptide-Induced Alzheimer’s Disease Pathophysiology(2020)
    Product Name: Beta-amyloid 1-42(GenicBio)
    Author List:  Rita F. Belo, Margarida L. F. Martins, Liana Shvachiy, etc.
    Journal: Front Pharmacol. 2020; 11: 985.
    Doi: 10.3389/fphar.2020.00985
         
        A pyrene-inhibitor fluorescent probe with large Stokes shift for the staining of Aβ1–42, α-synuclein, and amylin amyloid fibrils as well as amyloid- containing Staphylococcus aureus biofilms(2019)
    Product Name: Beta-amyloid 1-42(GenicBio)
    Author List: Alejandro Mahía, María Conde-Giménez, Sandra Salillas, etc.
    Journal: Analytical and Bioanalytical Chemistry
    Doi: https://doi.org/10.1007/s00216-018-1433-8
         
        The Effects of Cardiotrophin-1 on Early Synaptic Mitochondrial Dysfunction and Synaptic Pathology in APPswe/PS1dE9 Mice(2017)
    Product Name: Beta-amyloid 1-42(GenicBio)
    Author List: Wang, Dongmei; Liu, Xiaozhuan; Liu, Yumei; Li, Sanqiang; Wang, Chenying
    Journal: Journal of Alzheimer's Disease, vol. 59, no. 4, pp. 1255-1267, 2017
    DOI: 10.3233/JAD-170100
         
        Effect of Cholesterol on Membrane Fluidity and Association of Aβ Oligomers and Subsequent Neuronal Damage: A Double-Edged Sword(2018)
    Product Name: Beta-amyloid 1-42(GenicBio)
    Author List: Eduardo J. Fernández-Pérez, Fernando J. Sepúlveda, etc.
    Journal: Front. Aging Neurosci., 03 August 2018
    Doi: https://doi.org/10.3389/fnagi.2018.00226
         
        A Fluorescence‐Based Sensor Assay that Monitors General Protein Aggregation in Human Cells(2018)
    Product Name: Beta-amyloid 1-42(GenicBio)
    Author List: Marisa Pereira, Diogo Tomé, Ana S. Domingues, Ana S. Varanda, etc.
    Journal: Journal of Biotechnology
    Doi: https://doi.org/10.1002/biot.201700676
         
        Amyloid aggregation and membrane activity of the antimicrobial peptide uperin 3.5(2018)
    Product Name: Beta-amyloid 1-42(GenicBio)
    Author List: Lisandra L. Martin, Clemens Kubeil, Stefania Piantavigna, Tarun Tikkoo, etc.
    Journal: Journal of peptide science
    Doi: https://doi.org/10.1002/pep2.24052
         
        Rapamycin protects against Aβ-induced synaptotoxicity by increasing presynaptic activity in hippocampal neurons(2014)
    Product Name: Beta-amyloid 1-42(GenicBio)
    Author List: A.E.Ramírez, C.R.Pacheco,L.G.Aguayo
    Journal: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
    Doi: https://doi.org/10.1016/j.bbadis.2014.04.019
         
        Coat protein I depletion-associated Golgi fragmentation in an Alzheimer's disease model
    Product Name: Beta-amyloid 1-42(GenicBio)
    Author List: Mi Jeong Kim, A Reum Je, Hyo-Jeong Kim, etc.
    Journal: Journal of Animal Cells and Systems
    Doi: https://doi.org/10.1080/19768354.2014.984756
         
        Alzheimer's Aβ interacts with cellular prion protein inducing neuronal membrane damage and synaptotoxicity
    Product Name: Beta-amyloid 1-42(GenicBio)
    Author List: Christian Peters, María Paz Espinoza, Scarlet Gallegos, etc.
    Journal: Neurobiology of Aging
    Doi: https://doi.org/10.1016/j.neurobiolaging.2014.11.019
         
        Levetiracetam inhibits oligomeric Aβ-induced glutamate release from human astrocytes(2016)
    Product Name: Beta-amyloid 1-42(GenicBio)
    Author List: Sara Sanz-Blasco, Juan C. Pi?a-Crespo, Xiaofei Zhang, Scott R. McKercher, etc.
    Journal: Journal of Neuroreport
    Doi: 10.1097/WNR.0000000000000601
         
        Multifunctional Curcumin-Nanocarriers Based on Host-Guest Interactions for Alzheimer Disease Diagnostic(2015)
    Product Name: Beta-amyloid 1-42(GenicBio)
    Author List: Lamesh Ramdani, Romain Bourboulou, Mounir Belkouch, etc.
    Journal: Journal of Nanomedicine & Nanotechnology
    Doi: 10.4172/2157-7439.1000270
         
        The membrane-active amphibian peptide caerin 1.8 inhibits fibril formation of amyloid β1-42(2015)
    Product Name: Beta-amyloid 1-42(GenicBio)
    Author List: Yanqin Liu, Tianfang Wang, Antonio N.Calabrese, John A.Carver, etc.
    Journal: Journal of Peptides; Volume 73, November 2015, Pages 1-6
    Doi: https://doi.org/10.1016/j.peptides.2015.08.004
         
        Effects of dipole modifiers on channel-forming activity of amyloid and amyloid-like peptides in lipid bilayers(2015)
    Product Name: Beta-amyloid 1-42(GenicBio)
    Author List: S. S. Efimova, V. V. Zakharov & O. S. Ostroumova.
    Journal: Cell and Tissue Biology volume 9, pages250–259(2015)
    Doi: https://doi.org/10.1134/S1990519X15030049
         
        Amyloid-beta oligomerization is associated with the generation of a typical peptide fragment fingerprint(2016)
    Product Name: Beta-amyloid 1-42(GenicBio)
    Author List: Nikita Rudinskiy | Christophe Fuerer | Davide Demurtas | Sebastian Zamorano, etc.
    Journal: Alzheimer's & Dementia; Volume 12, Issue 9, September 2016, Pages 996-1013
    Doi: https://doi.org/10.1016/j.jalz.2016.03.011
         
        Differential Membrane Toxicity of Amyloid-β Fragments by Pore Forming Mechanisms(2016)
    Product Name: Beta-amyloid 1-42(GenicBio)
    Author List: Peters, Christian | Bascu?án, Denisse | Opazo, Carlos | Aguayo, Luis G.
    Journal: Journal of Alzheimer's Disease, vol. 51, no. 3, pp. 689-699, 2016
         
        Crystallization and preliminary X-ray diffraction analysis of the Fab portion of the Alzheimer's disease immunotherapy candidate bapineuzumab complexed with amyloid-[beta](2014)
    Product Name: Beta-amyloid 1-42(GenicBio)
    Author List: G. A. N. Crespi, D. B. Ascher, M. W. Parker and L. A. Miles
    Journal: CRYSTALLIZATION COMMUNICATIONS
         
        Exosomal cellular prion protein drives fibrillization of amyloid beta and counteracts amyloid beta‐mediated neurotoxicity(2015)
    P
    roduct Name: Beta-amyloid 1-42(GenicBio)
    Author List: Clemens Falker Alexander Hartmann Inga Guett Frank Dohler Hermann Altmeppen, etc.
    Journal: Journal of Neurochemistry
    Doi: https://doi.org/10.1111/jnc.13514
         
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